Statin-associated autoimmune myopathy
Statin-associated autoimmune myopathy (SAAM), also known as anti-HMGCR myopathy, is a very rare form of muscle damage caused by the immune system in people who take statin medications. However, there are cases of SAAM in patients who have not taken statin medication, and this can be explained by the exposure to natural sources of statin such as red yeast rice, which is statin rich. This theory is supported by the higher prevalence of statin-naive SAAM patients in Asian co… WebAug 22, 2024 · Myopathies are a heterogeneous group of disorders primarily affecting the skeletal muscle structure, metabolism or channel function. They usually present with muscle weakness interfering in daily life activities. Muscle pain is also a common finding and some myopathies are associated with rhabdomyolysis.
Statin-associated autoimmune myopathy
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WebFeb 28, 2024 · A drug-induced myopathy is defined as the manifestation of myopathic symptoms occurring in patients without prior muscle disease when exposed to certain … WebJan 1, 2015 · Keywords: Statin myopathy is a heterogenous condition Diagnosing statin-associated autoimmune myopathy is challenging but critical Anti HMGCR autoantibodies are useful in making the diagnosis ...
WebOct 6, 2004 · HMG-CoA reductase-induced myopathy occurs in 2% to 5% of statin-treated patients. This condition may proceed to rhabdomyolysis. Fortunately, this grave complication occurs rarely, perhaps in 1/100,000 patient-years of statin treatment. HMG-CoA reductase-induced myopathy is related to the dose of statin and is often due to drug … WebStatin-induced autoimmune necrotising myopathy causes a severe progressive muscle weakness even when the statins are discontinued. First-line treatment is usually with high …
WebThe composition of cellular infiltrates in anti-HMG-CoA reductase-associated myopathy WebIdiopathic inflammatory myopathies (IIMs) are a rare group of autoimmune diseases that can cause chronic inflammation of skeletal muscle and/or organs, including the skin, joints, lungs, gastrointestinal tract and heart.
WebFeb 18, 2016 · Statin-associated autoimmune myopathy is an exceptionally rare side effect of statin use. Its incidence is not known with certainty, but it is estimated to occur
WebApr 1, 2024 · Statin-associated myopathy comprises of a spectrum of conditions ranging from benign myalgias to statin-induced immune-mediated necrotizing myopathy. Statin-induced immune-mediated necrotizing myopathy is an autoimmune condition wherein there is a destruction of normal skeletal muscular architecture that can be severely debilitating … midwest recyclers davenport iaWebFeb 21, 2024 · Unexpectedly, the majority of the patients with anti-200/100 antibody had a history of statin exposure, providing the first link with statin-associated autoimmune myopathy. Shortly thereafter, HMGCR, which has a molecular weight of about 100 kDa and also forms a 200 kDa dimer, was identified as the autoantigen targeted by this antibody . … midwest recycled \u0026 coatedWebOct 1, 2024 · Statin-induced necrotizing autoimmune myopathy is a rare side effect of statin therapy characterized by muscle weakness and marked elevation of CPK. Diagnosis requires a high index of suspicion, especially with persistent elevation of CPK despite statin discontinuation. Diagnosis is confirmed by positive anti-HMG-CoA reductase … newton makes cutting boardsWebStatin-associated autoimmune myopathy is a relatively newly identified disorder, with first case reports published in the last 5 years, and autoantibodies were only recently identified … newton mall shopsWebFeb 18, 2016 · Statin-associated autoimmune myopathy is an exceptionally rare side effect of statin use. Its incidence is not known with certainty, but it is estimated to occur in approximately 2 or 3 of... It is associated with arthralgias in 50 to 60% of patients, as well as fever in 30% of … newton mail pricingWebDec 1, 2016 · Statin-associated autoimmune myopathy (SAAM) with anti-HMGCR antibodies has recently been described. Several specific immunoassays are in use to detect HMGCR antibodies. In the course of systematic autoantibody screening we recognized a new distinct IFL staining pattern on rat liver sections that regularly coincided with anti-HMGCR … newton ma interim school superintendentWebMar 4, 2024 · Mammen AL, Chung T, Christopher-Stine L, et al. Autoantibodies against 3-hydroxy-3-methylglutaryl-coenzyme A reductase in patients with statin-associated autoimmune myopathy. Arthritis Rheum 2011; 63:713. Chung T, Christopher-Stine L, Paik JJ, et al. The composition of cellular infiltrates in anti-HMG-CoA reductase-associated … midwest recyclers davenport iowa